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Nei pazienti che ricevono medicinali antipertensivi concomitanti, il tadalafil può indurre una riduzione della pressione del sangue.

Tadalafil (20 mg) è stato studiato in associazione a 4 classi di antipertensivi. Nei soggetti che assumevano più antipertensivi, le variazioni della pressione sanguigna controllata ambulatorialmente apparivano correlabili al grado di controllo della pressione sanguigna. Nei soggetti con pressione sanguigna ben controllata, la riduzione della pressione sanguigna era minima e simile a quella osservata nei soggetti sani.

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Disturbi della vista e casi di NAION sono stati segnalati in associazione all’uso di tadalafil ed altri inibitori della PDE5. Le analisi dei dati osservazionali suggeriscono un aumentato rischio di NAION acuta in uomini con disfunzione erettile dopo esposizione a tadalafil o altri inibitori della PDE5.

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